Michael, Lincoln and six other convicts, including pickpocket Tweener and the mentally unstable Haywire, have eventually escaped from Fox River. and the second season follows a vast manhunt trying to catch up the group. Dubbed the Fox River Eight, the group is separated and members are on their individual way, occasionally meeting up to help each other. They fight to run away from the police while avoiding The Company - a mysterious group who attempts to end their lives by all means.