“You Me and the Apocalypse” follows a group of people struggling with the end of the the world. Before the last day happens, a British bank manager Jamie Winton wants to search for his disappeared wife and his biological. Rhonda MacNeil, a prisoner, meets a white supremacist Leanne. Her brother Scotty and his boyfriend attempt to stop the comet, while at the Vatican, Father Jude Sutton along with Sister Celine try to look for potential Antichrist and the world’s saviour.